In Graves' disease, thyrotoxic crisis can present with which sign?

In Graves' disease, thyrotoxic crisis can present with which sign?

• A. Pallor
• B. Fever
• C. Bradycardia
• D. Weight gain

Answer: (B)

Thyrotoxic crisis, or thyroid storm, is an extreme, life‑threatening escalation of Graves’ disease driven by a massive surge in thyroid hormones and sympathetic activity. This hypermetabolic state generates heat production out of proportion to heat loss, so a high fever becomes a hallmark sign. Alongside the fever you’d expect tachycardia, sweating, agitation, and possible hypertension and weight loss from intensified metabolism. Pallor, bradycardia, or weight gain don’t fit this picture—bradycardia and weight gain are opposite to the typical hypermetabolic, hyperadrenergic response seen in a thyroid storm.

Thyrotoxic crisis, or thyroid storm, is an extreme, life‑threatening escalation of Graves’ disease driven by a massive surge in thyroid hormones and sympathetic activity. This hypermetabolic state generates heat production out of proportion to heat loss, so a high fever becomes a hallmark sign. Alongside the fever you’d expect tachycardia, sweating, agitation, and possible hypertension and weight loss from intensified metabolism. Pallor, bradycardia, or weight gain don’t fit this picture—bradycardia and weight gain are opposite to the typical hypermetabolic, hyperadrenergic response seen in a thyroid storm.